Research news

October 2024 update

A summary of the Parkinson's research in this month's update from Zhittya Genesis Medicine, with the complete update underneath.

Back to the research page · Open the original update (PDF)

In short

Dr. Jack Jacobs presented the Parkinson's research at a hospital meeting in Kuwait. The update restated Zhittya's hypothesis that Parkinson's and related conditions may begin with poor blood vessel function in the brain.

The October update opened with a letter from the husband of a participant who had a stroke three days before her first FGF-1 dosing, about nine months earlier. He described changes in her alertness, speech, daily tasks and walking. CEO Dan Montano wrote that she was the second participant with a stroke in the research studies, and that both still had a long way to go.

A large part of this update covered other topics, which are not carried here.

The hypothesis, restated

Mr. Montano set out the idea behind the research in plain terms. "I believe Parkinson's disease and most neurodegenerative diseases are the result of dysfunctional vascular blood flow in the brain," he wrote. In his view, blood vessels become weakened or damaged, and less blood reaches brain cells. He noted that this is already accepted as the cause of stroke, vascular dementia and vascular parkinsonism, and said he believes the same problem is far more widespread.

He offered several supporting points, each tied to outside sources. The first was a presentation from a neuroscience center in Toronto on tiny strokes that go unnoticed but add up over many years. The second was damage to the cells that line blood vessels, covered in Dr. Jacobs's section.

The third was the brain's system for clearing cellular waste, which he said was first described in 2013. He linked this to the earlier monkey study, done by researchers outside Zhittya. In his reading, new blood vessels in those animals brought fresh blood flow that helped carry waste away.

The fourth was a presentation on the so-called "Parkinson's Belt," areas where Parkinson's is more common, in which a research neurologist discussed chemical exposure as a possible cause. Mr. Montano added what he called his own guess: that such chemicals may damage the cells lining blood vessels, leading to leaks and tiny strokes.

Dr. Jacobs on leaky vessels

Dr. Jack Jacobs explained the vessel lining in more detail. Blood vessels are lined with a single layer of endothelial cells, which lets small molecules such as oxygen, water and glucose through but normally holds back blood cells and proteins. If the layer is damaged, leaks can develop. Tissue then gets less blood and is exposed to substances that should never leave the bloodstream.

He wrote that a growing body of evidence suggests such leaks may be an early event in several brain disorders, including Parkinson's, Alzheimer's and multiple sclerosis. Long-lasting vessel problems can also lead to shrinkage of the brain.

He again described a published mouse study of multiple sclerosis, in which a damaged vessel lining appeared well ordered after 30 days of FGF-1. If a similar process is at work in Parkinson's, he wrote, it makes sense to study whether FGF-1 could help there too.

Kuwait, and where things stood

On October 4, Dr. Jacobs spoke on new approaches to Parkinson's at Dar Al Shifa Hospital, which the update called the largest private hospital in Kuwait. The update said the talk was well received.

By October, 188 people with Parkinson's had been dosed. Mr. Montano wrote that some showed large improvement and some less. "Do we have the answer for Parkinson's disease? Probably not yet, but we are improving every month," he wrote.

The first participant scanned at Washington University in St. Louis had since been dosed and was due for a second scan in December. Would it show more blood flow to the substantia nigra, the area tied to Parkinson's? "I do not know today," Mr. Montano wrote, adding that he hoped to have the answer in January 2025.

Two participants' comments were also shared, on tremor, walking, mood, energy and a neurologist's remarks. The rest of the update covered other research areas and company matters.

This summary covers the Parkinson's research in the October 2024 update. The complete update, including the other topics it covered, is below.

Read the complete October 2024 update as published

The text of the update Zhittya sent, word for word. Pictures, charts and layout are in the PDF. Open the PDF.

October 17, 2024, Monthly Update

Great News!

Every morning, I wake up excited by the tasks I have in front of me each day. I am blessed to have a purpose and a burning passion to succeed. One of our test subjects is a woman whom we invited to the British Virgin Islands (BVI) about 9 months ago to be treated for her Parkinson’s disease. When she arrived, she was in worse condition than when we had interviewed her only two weeks before. She could not walk and was in a wheelchair in a very diminished condition, with serious speech and movement issues. Her husband asked us to proceed with treating her. We did not know, nor did he at that time, that she had suffered a stroke 3 days prior to arriving in the BVI. When her doctors later informed the husband that his wife had suffered a serious stroke, he informed us of that about two weeks after she had left the BVI. Below, I have copied an email he sent me on October 10th detailing her remarkable recovery so far. I have placed this email at the beginning of this Monthly Update, so everyone understands two things:

One: Our medicine seems to be working and patients are improving, with her as an amazing example.

Two: These types of emails are the real reward of our efforts. I made a lot of money as an Investment Banker for 30 years, however that reward is nothing compared to knowing you helped a wonderful woman recover from a horrible stroke and that she is regaining her life. My wonderful aunt had a stroke in 2006, and she became a vegetable overnight. That is when Dr. Jacobs started our program for enhanced stroke recovery. The woman mentioned above is our second stroke recovery test subject and the first stroke test subject has also seen a dramatic improvement. I am so very happy that these two patients are recovering from their strokes, but they still have a long way to go to reach a full recovery. We now know that extended dosing with FGF-1 enhances recovery with Parkinson’s disease patients and stroke subjects. Please read her husband’s email to Vika below, and I hope for millions of people who suffer from a stroke that we are on the right path!

Dear Vika / Dan:

It has been 9 and a half months since we were in the BVI and Gail had her first dosing.

If you remember, 3 days earlier she had experienced a significant stroke and was wheelchair bound.

She could not feed herself, comb her hair and her cognitive abilities had been affected.

She could not use her phone or even the TV remote.

She had trouble speaking and was prone to falling asleep, even when talking with friends.

We have followed the dosing protocol exactly as you had prescribed.

The change in Gail has been miraculous.

She is much more alert and her sense of humor has returned.

Her cognitive abilities have returned, and she is now, once again, using her phone for email, text messages and phone calls.

After the stroke, she forgot how to turn on the TV with the remote, and often tried to turn on the TV with her phone.

Now she can turn on the TV, change stations, etc.

She can now feed herself including cutting food with a knife and use condiments.

Most importantly, she is learning to walk again with a walker.

Her caretaker has her walking 15 – 30 minutes a day.

Initially, she would take a few steps, pause, and take a few more steps.

Now, she can walk from the living room to the bathroom without stopping.

She even can walk up 6 – 7 stairs, just holding on to the railing.

Initially, she used to dread the dosing protocol.

Now she looks forward to it because she sees the benefits of it.

I would think that some of her progress would be normal after a stroke, but the degree of progress and the speed with which it has occurred, has to be attributed to the dosing.

Friends that saw Gail 2 – 3 months after her stroke are actually stunned to see how she is today.

Thanks for all your help,

Skip

Preface

Now for the part you will not like. Let me start by apologizing to many of you for offending your beliefs in your doctors, big pharma, elite academia, and charitable organizations. I am so tired of people dismissing our amazing medical efforts and impressive human success with our medicine with the ignorant phrase of, “If what you have is real, then Big Pharma or a charitable organization like the Parkinson’s Foundation would be supporting you”. I am so tired of hearing, “My neurologist does not believe you are real, so you must be a fraud”.

Did COVID-19 teach you nothing? The so-called experts are paid to say what they are told to say, they are “paid spokespersons”. The same experts said that an untested COVID-19 vaccine has no adverse side effects and would protect you from COVID-19. Today we know that the vaccine did have adverse side effects, and, in fact, some vaccines were removed from the market because of the danger it posed to the public (Independent UK). COVID-19 still remains with us, even after a mass vaccination program intended to eradicate the disease. When it comes to Parkinson’s disease, many of you believe the same experts who freely admit to you that they do not know what causes Parkinson’s disease or how to reverse it. Those experts tell you that there is no cure or healing for Parkinson’s disease, and yet they continue to prescribe the same dopamine medications (discovered and approved in 1968) that they have for the last 55 years. A medicine which was a miracle at reducing the symptoms of Parkinson’s disease at its founding 55 years ago, however, has not cured one person in those 55 years. I may be stupid, and I may be unlucky, but I am not following the advice from expert neurologists and Parkinson’s disease charities, when it comes to treating Parkinson’s disease. If these medicines have not healed one person in 55 years, it would be insane to try the same old thing over and over again, expecting a better outcome. I believe that is the definition of “insanity.”

You do not have to believe me. But everyone, including these charitable organizations, experts, and doctors, should open their minds to what may be the truth: Parkinson’s disease is a disease of vascular dysfunction in the brain.

I am 76 years old. I was born very poor in East Los Angeles, with a Mexican father and a Scottish-Irish mother. I started on the floor of the Los Angeles Stock Exchange in 1968 at the age of 20. I read that people who were rich made their money on Wall Street and I wanted to be rich, so I went to the closest thing in California that was Wall Street: The Los Angeles Stock Exchange. For the next 30 years, I was an Investment Banker in California and London, and I raised hundreds of millions of dollars for over 100 new high-tech ventures; companies who made mini-computers, micro-computers, microprocessors, semiconductors, medical devices and more. Some of these companies competed with computers made by IBM, Honeywell and General Electric, and we won against them because we had better results for the consumer! New creative innovations generate enhanced products and improvements for the consumers. I started many high-tech ventures, raised the capital and operated a few as the CEO and was successful.

We had an idea for a better and more economical answer for customers' needs and in the free-market competition, we won!

When I started this biotech venture 25 years ago, it never entered my mind that the barriers the established medical industry would put up to try to stop advancing our medicine would be so overwhelming, so crushing and designed to defer or destroy challengers. Big Pharma, Elite Academia, and charitable organizations stop competition and squash new medicines. I personally believe 70% of the amazing biological discoverers of the last 40 years (1980 to 2020) remain on the research shelf, ignored because the barriers that have been put in place are huge. What good is a biotech medical breakthrough if it never gets to the patients?

With this Update, I pray that I can help open your eyes to the reality that people are suffering and dying needlessly because of the falsities of modern medicine that comes from Elite Academia, Big Pharma, key opinion makers (bought and paid for) and the charitable organizations that all profit from the barriers to stop the advancement of better medicines. I believe they do more harm than good, and they lessen your objective to have a better life for yourself and your loved ones. I will not tell you stories, but I will provide you links to stories written by others to verify what I say is true. You do not have to believe what I say, but for your own sake at least listen to others, and maybe we can make the world better together. Some people do not have 18 years to wait for the USA FDA to clear a medicine that could save their lives today.

Hypothesis:

I believe Parkinson’s disease and most neurodegenerative diseases are the result of dysfunctional vascular blood flow in the brain.

I believe that critical blood flow is disrupted because the blood vessels are weakened or damaged, thereby lessening or halting blood flow to cells in the brain. We know that is exactly what causes a stroke, vascular dementia, and vascular parkinsonism. It is possible that vascular disruption is more widely spread in the brain than your doctor, who studied medicine 40 years ago, realizes today. I believe Parkinson’s Disease, dementia, Alzheimer’s disease, multiple sclerosis and more are all vascular diseases of the brain.

Tiny/Mini/Micro Strokes:

If you are over the age of 55, I believe you are having tiny mini- and micro- strokes all the time. If you were exposed to noxious chemicals at age 20, I believe those chemicals could have weakened your vascular cells causing you to have mini/micro strokes on a monthly, weekly or even daily basis. Here is a link to a presentation by Krembil Neuroscience Centre in Toronto, Canada on these “tiny” strokes. These tiny strokes aren't felt or even often realized except as they accumulate in the brain over many years, until they reach the point where you cannot even remember your own mother’s name: https://youtu.be/J3fb0CaDpEk?si=j4oHicIIVrp8AluK Watch this video and even if you do not believe it, think about how easily this explains neurodegenerative diseases, such as Parkinson’s disease, dementia, Alzheimer’s disease, and more. Tiny strokes interfere with the transportation of blood to brain cells, thereby diminishing their ability to function properly. Isn’t this common sense?

Point One:

You could be suffering from endothelial cell dysfunction without realizing it. This is the reason Dr. Jacobs, Vika, and I took FGF-1 to potentially repair, defer or delay endothelial dysfunction so we can keep remembering our mothers’ names. Please see Dr. Jacobs’ section later on in this Update, where he gives a more detailed discussion on the topic of endothelial cell dysfunction.

Point Two:

Scientists are learning about brain trash disposal. Please note, this discovery of how the brain removes cellular waste was first discovered in 2013. Keep in mind that 2013 was just over 10 years ago, and your neurologist most likely had graduated from medical school many years before this discovery. The same neurologists who say that “Zhittya’s work on Parkinson’s disease is phony” are the same neurologists who give 15 minutes of their time, every 6 months, to prescribe you medicine that only delays your inevitable suffering. Your neurologist gets paid to meet with you. He does not get paid to do research on treatments not yet approved by the FDA. He does not read the most recent theory on how brain waste is removed. Until our medicine is approved by the USA FDA, and we spend millions of dollars educating your neurologist on what our medicine can do and show him how he can get paid for using our medicine, your neurologist does not care about what we are doing. Also, about 8% of our 188 Parkinson’s disease test subjects are medical doctors and one is a neurologist.

They believe in what we are doing, since they know the treatments presently offered now do not heal their Parkinson’s disease.

Read the article cited below and then in your next 15 minutes of paid time with your neurologist, ask them how cellular brain waste is removed? If he/she does not know, then they should watch Dr. Jacobs’s presentation on the monkeys with Parkinson’s disease who were treated with FGF-1. The FGF-1 created new blood vessels, where the fresh blood flow from the new vessels washed the cellular trash away. It will most likely be news to your neurologist.

Link: Scientists Picked Apart the Human Brain's Trash Disposal—and Found Something Incredible (msn.com)

Point Three:

Below is a link to an excellent presentation on the “Parkinson’s Belt”. These are areas where Parkinson’s disease is more common, places that include Pittsburgh, Fresno and other locations. When you watch this, listen to the research neurologist discuss how he believes exposure to chemicals can lead to Parkinson’s disease. How does this occur? My guess is those chemicals irritate, or interfere with, the normal repair or adhesion of endothelial cells that make up your blood vessels. If you have weakness and leaks in your blood vessels, then you will have holes in your blood vessels, resulting in mini-strokes and vascular dysfunction.

Link: https://youtu.be/7mYEqUrx6dQ?si=-8HvnPFgagI7AqDr

Point Four:

Now for the part that makes you hate me: THE TRUTH

Below is a link to a long article on the corruption of disease-focused charities.

When I started this adventure 26 years ago, I believed if you showed the world that you had something better that would save millions of lives and lessen suffering, many people would step up and support you. Wow, was I wrong!

Our medicine to grow blood vessels in the heart is a tremendous medical breakthrough, and it should save millions of lives every year. It will replace most of the need for heart stents. We struggled to get interventional cardiologists to be in our FDA-cleared Phase II clinical trial, which utilized a catheter to deliver the medicine. If we had succeeded, then the demand for PTCA (percutaneous transluminal coronary angioplasty) and stents would have evaporated and cardiologists would have lost their most profitable therapy. The choice between what could be great for their patients in the future versus their personal profits now, meant the patients lost. We have reached out to every Parkinson’s disease organization we can find in the world. Organizations in the UK, Germany, Singapore, Saudi Arabia, Canada, the United States and many more countries.

They will not even talk to us. They raise hundreds of millions of dollars and have discovered nothing in 20+ years. With the monkey data we reached out to them and said: “Look, Parkinson’s disease was reversed in these monkeys, and we do not need your money, but just please watch what we are doing. When we give you human proof that FGF-1 can reverse Parkinson’s disease (like in the monkeys), then you can assist us in getting this drug approved for your people”.

Not one of those organizations in ten years has ever replied. Not one! When we talk to Elite Academia, they want to know how much we are going to pay them.

We have been denied participation in Parkinson’s disease gatherings because the promoters tell us that their Big Pharma sponsors will drop out and not support them if someone like us presents at the meeting. Big Pharma wants no one to talk about curing Parkinson’s disease, since they sell and profit from drugs that do not cure anything.

Read this email which came to us from a friend who understands the corruption of many of the charity organizations. They do not work for a cure; they work for their salaries and their need to keep the disease going for their job security.

“Dan, Vika, Jack & Sergiy -

As we know, charities that are supposed to raise money for a "cure" never do and might be blocking good treatments.

The National Multiple Sclerosis Society took in 172 million dollars last year and is notorious for blocking many proven treatments for MS from seeing the light of day, while continuously supporting lucrative new drugs to “manage” the disease.”

For your sake and for the sake of those that you love, if you don't believe me, look at “Shirky’s Principle”.

Clay Shirky is an NYU professor, American writer, and economist, who has studied modern institutions and social networks, where he famously developed Shirky’s Principle, stating: “Institutions will try to preserve the problem to which they claim they are the solution.” (Dr. Itamar Shatz, Cambridge University and Clay Shirky in Cognitive Surplus): https://effectiviology.com/shirky-principle/.

The article above gives countless examples of Shirky’s Principle in action; however, we have attached below a number of examples of the same institutions and doctors, blocking, stopping, or lying about their research.

The Huffington Post: Susan G. Komen Cancer Foundation Sues Other Charities using the word “Cure”: https://www.huffpost.com/entry/komen-foundation-charities-cure_n_793176.

The Guardian: There’s Far More Scientific Fraud than Anyone Wants to Admit: https://www.theguardian.com/commentisfree/2023/aug/09/scientific- misconduct-retraction-watch.

National Health Institute: Fraud and Misconduct in Clinical Research: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700330/.

The British Medical Journal: The European Medicines Agency Covid-19 Data Leak questions effectiveness and quality of initial doses of COVID-19 vaccine: https://www.bmj.com/content/372/bmj.n627.

National Health Institute: Multiple Sclerosis Onset resulting from initial COVID-19 Vaccine Doses: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656147/.

I want our readers to note. This is from a brief search on the Internet on the corruption of our current medical industry. All the articles we have attached above are not only published but have been peer-reviewed by some of the best academics in the USA and Great Britain. All reached the same conclusion: The same institutions who vow to protect you, have lied, cheated, and bamboozled you. The articles, once again, underly the truth behind Shirky’s Principle:

“Institutions will try to preserve the problem to which they claim they are the solution”.

For those of you who keep saying to me: “Well, if you were real, Big Pharma, Elite Academia and the charities for these diseases would be helping you!” They do everything they can to stop us because we are a threat to their profits of selling you something they know will never cure you. They want you to think that we are a fraud. Open your eyes!

My father was a tough man who lived through the Great Depression and fought for everything in his life to succeed. He used to warn my older brother and me by saying: “If you threaten another man’s rice bowl, be prepared for the fight of your life.” I foolishly believed that saving lives and lessening suffering would overcome my father’s warning, but I was wrong. Even with the amazing human evidence that we may have a treatment to reverse Parkinson’s disease, we still stand alone.

We stand criticized and condemned. I guess the good news is that it is not the first time in my life that I have “to fight the unbeatable foe”. The difference this time is I am not fighting to make more money; I am fighting to save millions of lives and to know my life had purpose!

I pray you forgive me for breaking your innocence on the brutal corruption that causes all of us more suffering. Since I was a teenager, I have listened to the song “The Impossible Dream.” To go where wise men, fear to tread, is to me a given reality. Plus, I always believed Don Quixote was a pessimist compared to me! The advantage of being a crazy optimist is you do not know how to quit or to lose. You know you have to succeed, since others are in need of your success.

Kuwait

Quick note: Dr. Jacobs gave his presentation on “New Modalities for Treatment of Parkinson’s Disease”, on October 4th at the auditorium at the Dar Al Shifa Hospital, the largest private hospital in Kuwait. It was a wonderful success, and it is interesting that when you get outside the western world’s medical mob of big pharma paying the “key opinion makers” to push their products, other medical doctors look at the medical science and like what they see.

Here is a picture of Dr. Jacobs at the podium giving his presentation.

Our ten-day trip to Kuwait allowed us to have private meetings with some of our shareholders/investors there, and also with medical and business people who grasp what our medicine can do for patients and the business potential for them.

It is nice to be appreciated somewhere. We are advancing.

Vika Montano’s Patients’ Comments Section: Every month, I receive emails and phone calls from our test subjects. September is a big month for redosing our test subjects. We receive more emails when people are preparing for the next round of FGF-1 dosing. Here I have selected a few of their comments so you can read what those who have joined our Medical Research Studies are reporting to us.

Patient One:

Hi Vika and crew,

I think FGF-1 is amazing. I have had Parkinson's for 20 years. The last few years have been downhill, especially after I had broken a few bones. So, when we heard about the study, I decided it was definitely something we should try. If not for us, for all of those suffering from PD. In a few months after being dosed in BVI.

I began to feel like my old self again. My tremor was better, my step was higher, my mood definitely better. Things are not perfect of course, but I will take whatever help I can get and that seems to be FGF1.

There is one other thing that Is a good side effect.

Patient Two:

Dear Vika

Thank you for your email.

I am feeling overall some better. I seem to have more energy. I have less constipation. And there are periods when I feel my gait is normal or improved.

I have been suffering from sciatica for about 2 weeks and is on the same side as my illness which affects me the most. I am not sure if it is progression of my illness or simply sciatica.

I did see my neurologist in August after my trip to begin treatment with fgf-1 at BVI in July, 2024 and before my sciatica symptoms bothered me. When I saw my neurologist Dr. xxxxxx, she said that the treatment with fgf-1 has a "promising theory." And at the end of my visit, she ended by saying, " You are doing good."

These 2 comments that she made were uplifting and continued to support what I already knew about the treatment with fgf-1. She left me with a positive feeling. I felt she was on my side with the course of treatment I found with Zhittya.

I am hoping the symptoms of sciatica will resolve with a course of Advil prn dosing. I have not reduced my dose of carbalevodopa just yet due to periods when I don't walk just right because these periods seem worse than my prior periods of poor gait. These periods of worsening gait are associated with stiffer and slower movement. I am grateful and elated when the periods of improved gait are with me.

Thank you for all that you have done to help me along the way. I am forever grateful. I will continue with the protocol to finish the remaining FGF-1 that I have left.

With appreciation,

R. Christy xxxxxxx

Cross Border Medical Tourism Cross Border Medical Tourism services is for those people who want to be considered for Zhittya’s future clinical trials or its current Medical Research Studies. Cross Border’s focus is to fill all available slots in the Medical Research Studies in the British Virgin Islands and The Bahamas, while we wait for other clinics to come online.

Cross Border is working on filling the available slots for the next BVI Medical Research Studies (intranasal FGF-1 for Parkinson’s disease) on the following dates:

Cohort #29: October 22, 2024 – October 27, 2024

Cohort #30: November 12, 2024 – November 17, 2024

Cohort #31: December 9, 2024 – December 14, 2024

Cohort #32: January 7, 2025 – January 12, 2025

Cohort #33: February 4, 2025 – February 9, 2025

Cohort #34: March 10, 2024 – March 15, 2025

I am showing cohorts further out in time since we are filling up faster and have fewer spots open each month.

Please contact Sam Cross at Cross Border Medical if you wish to be considered for the BVI cohorts or slots in The Bahamas. Sam’s email address is: sam.crossbordermedical@gmail.com.

In addition, if you are interested in participating in the brain scan studies which will take place at Washington University in St. Louis, please let Sam know. There are a finite number of slots for the imaging studies. These studies will look at brain blood flow before and after treatment with FGF-1. There has been no reported pain associated with the MRI scan.

Heart Disease Clinical Trials and Medical Research Studies:

Zhittya is proud to announce that it is beginning its active recruiting and selection process for patients suffering from late-stage heart disease. FGF-1 was originally used in USA FDA clinical trials to treat severe coronary artery disease. The treatment was shown to be safe and a potentially efficacious treatment for those suffering from coronary heart disease. Watch this ABC Nightly News’ clip on Zhittya’s drug being used for the heart indication: https://www.youtube.com/watch?v=IPtv_0LWK4k Zhittya is now actively recruiting patients to participate in Zhittya’s Medical Research Studies in The Bahamas, as well as future USA FDA clinical trials. If you are interested in participating in these studies, please reach out to Sergiy Montano, our Vice President of Marketing at: sergiy@zhittyamedicine.com and he will assist you from there.

Pre-IPO Private Placement

Bart Vossen is still working with people interested in learning more about the Pre- IPO placement we are conducting. If you are an investor and wish to learn more, please email Bart at: bhvossen.rmena@gmail.com I am hopeful the IPO will occur early in 2025.

Upcoming events:

Presently, we have nothing pending but will keep you posted in future Monthly Updates.

Dr. Jack Jacobs

As Dan mentioned earlier in this Update, we all are most likely suffering from a condition known as “endothelial cell dysfunction” without realizing it. This is the reason that Dan, Vika and I took FGF-1 to potentially repair, defer or delay endothelial cell dysfunction in hopes of keeping our brains functioning well and helping our memories stay intact. As shown in the figure below, the blood vessels in our bodies are lined with a single layer of endothelial cells.

These flattened cells form the natural barrier between our circulatory system and outside tissues. The endothelial cells are permeable to small molecules such as oxygen, water and glucose, which is important, as this is the way the body nourishes all our living cells. However, larger molecules, such as red and white blood cells, immune cells and proteins cannot freely cross the endothelial cell barrier. The picture above shows a normal, healthy artery that contains a single layer of endothelial cells along with multiple layers of smooth muscle cells that allow the artery to relax and constrict, thereby regulating the amount of blood that flows into a tissue or organ. If the endothelial cell layer of a blood vessel becomes damaged, as shown in the figure below, vascular “leaks” can develop.

There is a growing body of evidence that vascular leaks resulting from blood vessel dysfunction may be an initiating event in many neurodegenerative brain disorders, including Parkinson’s disease, Alzheimer’s disease, multiple sclerosis and more. As shown in the figure below, leaky arteries or capillaries not only reduce blood perfusion to tissues, but also expose the tissue to potentially harmful substances in the blood (for example, enzymes, immune cells, blood clotting factors) that never should escape the blood vessels.

Clearly, new therapies that can attack and reverse this vascular dysfunction, which we and others believe is the root cause of these diseases, are desperately needed. Chronic vascular dysfunction in the brain can lead to brain atrophy or shrinkage of the brain, a condition which is often seen on autopsy in patients with Alzheimer’s disease, multiple systems atrophy (MSA) and stroke.

There is excellent evidence that our very own FGF-1 can heal this endothelial cell dysfunction in an animal model of multiple sclerosis. The figure below shows the inside of a blood vessel which was located within a multiple sclerosis lesion in the spinal cord of a mouse. The left side of the figure shows a blood vessel ravaged with endothelial cell dysfunction, where the endothelial cell layer has become damaged and deformed. As the animal is treated with FGF-1 over a 30-day period, a remarkable “healing” of the endothelial cell layer is evident at day 30 where the inside of the blood vessel is now filled with a well-ordered and healthy array of endothelial cells.

The authors of this medical research paper speculate that this endothelial cell dysfunction may be the initiating event in the onset of multiple sclerosis and lead to the progression of the disease process. If a similar process is at work in other neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease, it makes all the sense in the world to see if FGF-1 could have a beneficial effect in reversing those devastating brain disorders as well.

Conclusion by Dan Montano

I am sorry to many of you if you are offended by my attack on your medical doctors, elite medical academies and the charities that claim to care about you.

Accepted medical practices once included bloodletting, and one example of this is where medical doctors bled George Washington to his death. That practice is no longer the standard of care. The world advances with new discoveries, and so must you if you wish the benefits of medical discoveries. Innovation of new medical treatments means trying something new!

To date, we have dosed 188 Parkinson’s disease patients. Some are showing amazing improvement, some less so, but none have regressed. Do we have the answer for Parkinson’s disease? Probably not yet, but we are improving every month. The first person who had his brain scanned at Washington University, St. Louis to measure the blood flow in his brain before FGF-1 treatment, has now been dosed and he will be rescanned this December. Will the scan show increased blood flow in his brain to the substantia nigra? I do not know today. I hope to know in January 2025, and if the answer is yes, it did, then we are on the right path. Knowing if our medicine can enhance cerebral blood flow in the brain is a big positive for everyone!

Zhittya has many ongoing projects, which we have never disclosed in these Updates, since we want results before we tell the world. I am very proud of our staff, our business partners, our investors, our test subjects and our true believers. Every morning when I wake up, I am excited by what we have going on.

The year 2024 is passing very fast and 2025 is now only ten weeks away. I believe in 2025 we will have amazing data that will open the floodgates of acceptance that we have something which can save millions of people from suffering and death.

I have many shortcomings. I am the father of six, grandfather to 11 and great- grandfather to 8. I believe people who know me would say that in spite of my many shortcomings, I am a good father, grandfather and great-grandfather. I love my children, grandchildren and great-grandchildren. I thank God every night that I have not failed them. I give you my word - I do not know if we can save millions of lives from heart disease, neurodegenerative disease, lung, diabetes, cancer and more, but like a good father I will do my best for those people who are suffering.

That is the purpose of my life, and I have been blessed to have a purpose!

May God bless all of us and show us the way to end these horrible diseases.

Dan Montano, CEO

Zhittya Genesis Medicine

1120 North Town Center Drive, Suite #270,

Las Vegas, Nevada 89144

United States of America zgm.care

<https://www.independent.co.uk/news/science/astrazeneca-covid-vaccine-withdraw-blood-clots-b2541291.html> <https://youtu.be/J3fb0CaDpEk?si=j4oHicIIVrp8AluK> <https://www.msn.com/en-us/health/other/scientists-picked-apart-the-human-brain-s-trash-disposal-and-found-something-incredible/ar-AA1owuXZ?ocid=msedgdhp&pc=LCTS&cvid=81c0f5ca097645339e404e0be464d1c6&ei=24> <https://www.msn.com/en-us/health/other/scientists-picked-apart-the-human-brain-s-trash-disposal-and-found-something-incredible/ar-AA1owuXZ?ocid=msedgdhp&pc=LCTS&cvid=81c0f5ca097645339e404e0be464d1c6&ei=24> <https://youtu.be/7mYEqUrx6dQ?si=-8HvnPFgagI7AqDr> <https://effectiviology.com/shirky-principle/> <https://www.huffpost.com/entry/komen-foundation-charities-cure_n_793176> <https://www.theguardian.com/commentisfree/2023/aug/09/scientific-misconduct-retraction-watch> <https://www.theguardian.com/commentisfree/2023/aug/09/scientific-misconduct-retraction-watch> <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700330/> <https://www.bmj.com/content/372/bmj.n627> <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656147/> [mailto:sam.crossbordermedical@gmail.com](mailto:sam.crossbordermedical@gmail.com)

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